280 - Sex Dimorphic Associations Between Oxidative Stress and Adiposity in Early Childhood

Publication Number: 280.6993

ZILIN CHEN, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, Shanghai, China (People's Republic); Zhongcheng Luo, Institute of Health Policy, Management and Evaluation,, Toronto, ON, Canada

Background: Oxidative stress may play an important role in the pathogenesis of obesity. There is a lack of studies on oxidative stress and obesity/adiposity in early childhood.

Objective: To investigate the relationship between oxidative stress and adiposity in early childhood.

Design/Methods: We conducted a nested case–control study including 120 pairs of overweight/obese and normal-weight children at age 4 years in the Shanghai Birth Cohort. We measured urinary oxidative stress biomarkers 8-isoprostane and 8-hydroxy-2-deoxyguanosine (8-OHdG), and assessed their associations with obesity/overweight and adiposity indicators [body mass index (BMI, z-score), body fat mass (BFM) and percent body fat (PBF)].

Results: Urinary 8-isoprostane levels were significantly higher in overweight/obese vs. normal weight children（2.08±1.73 vs 1.66±0.99 ng/mg creatinine) overall. Positive associations were observed between 8-isoprostane and BMI z-score (r =0.21, P < 0.001), BFM (r =0.17, P =0.02) and PBF (r =0.15, P =0.04). Sex-stratified analyses showed that these associations were restricted to males. Adjusting for maternal and child factors, one log unit increment in 8-isoprostane was associated with a 0.74 increase (P < 0.001) in BMI z-score in males, but there was no association in females.

Conclusion(s): Oxidative stress levels were elevated in overweight/obese subjects in early childhood, and could be positively correlated with adiposity in early childhood. These associations appear to be restricted to males, suggesting a potential sex-dimorphic role of oxidative stress in the development of childhood obesity.

Table The associations between log transformed 8-isoprostane and body composition metrics at 4 years
Table The associations between log transformed 8-isoprostane and body composition metrics at 4 years .pdf