WIP 69 - Psychiatric Comorbidities in Children with Osteogenesis Imperfecta: A Systematic Review of Mental Health Impact and Therapeutic Strategies

Publication Number: WIP 69.7360

Julia M. Morales, Baylor College of Medicine, Houston, TX, United States; Camille F. Villar, Baylor College of Medicine, Houston, TX, United States; Beatriz Varman, Texas Medical Center Library, Houston, TX, United States; Gianna Colombo, Baylor College of Medicine, Houston, TX, United States; Danqi Li, Baylor College of Medicine, Houston, TX, United States; Sarah J. Sadek, Baylor College of Medicine, Houston, TX, United States; Marie-Eve Robinson, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada; Chaya N. Murali, Baylor College of Medicine, Houston, TX, United States; Brendan Lee, Baylor College of Medicine, Houston, TX, United States; Vernon Reid Sutton, Baylor College of Medicine, Houston, TX, United States; Eric A.. Storch, BAYLOR COLLEGE OF MEDICINE, Houston, TX, United States; Andrew D.. Wiese, Baylor College of Medicine, Houston, TX, United States

Background: Osteogenesis imperfecta (OI) is a genetic disorder commonly caused by defects in type I collagen, leading to skeletal and extra-skeletal symptoms. The physical impacts are well-documented; however, mental health challenges among youth with OI remain poorly understood, inconsistent, and understudied. Research on other pediatric chronic conditions has shown significant associations with psychiatric disorders, suggesting similar risks in children with OI.

Objective: A systematic review is being conducted to evaluate the prevalence of psychiatric symptoms and interventions, including psychotherapeutic and psychopharmacological among youth with OI. This study seeks to provide insights for improving overall outcomes for children with OI.

Design/Methods: PRISMA guidelines were followed, and a comprehensive literature search was completed across Medline (Ovid), Embase (Elsevier), PsycInfo (Ovid), The Cochrane Library (Wiley), and Web of Science (Clarivate), using Medical Subject Headings and relevant keywords. The search yielded 995 studies.
Two independent reviewers are currently screening studies based on predefined inclusion and exclusion criteria, resolving discrepancies with a third reviewer. The inclusion criteria consist of peer-reviewed English studies on youth patients under 18 with any type of OI that assessed psychiatric comorbidities or evaluated interventions for managing these conditions. Screening is expected to conclude by mid-November 2024.
Data extraction and bias assessment will be completed by late January 2025. Extracted data will include study design, population characteristics, mental health outcomes, and psychological/psychiatric treatment effectiveness. The final stage will involve synthesizing the findings on psychiatric comorbidities and therapeutic interventions managing mental health conditions in children with OI, with completion expected by early spring 2025.