WIP 57 - Prevalence of hypertension and ambulatory blood pressure monitoring phenotypes among girls with Turner Syndrome

Publication Number: WIP 57.7694

Kelsi E. Alexander, Seattle Children's, Seattle, WA, United States; Miranda Bradford, Seattle Children's Research Institute, Seattle, WA, United States; Luciana Young, Seattle Children's Hospital/University of Washington, Seattle, WA, United States; Joseph T. Flynn, University of Washington, Seattle, WA, United States; Yosuke Miyashita, University of Washington School of Medicine, Seattle, WA, United States; Susan Halbach, University of WA/Seattle Children's Hospital, Seattle, WA, United States

Background: Hypertension (HTN) is a common, modifiable risk factor for cardiovascular mortality in girls with Turner Syndrome (TS). Prior blood pressure (BP) studies including those with use of ambulatory blood pressure monitoring (ABPM) have been conducted in small cohorts and have shown wide variability in prevalence. There is a lack of recent studies in girls with TS using the American Heart Association (AHA) 2022 ABPM guidelines, nor have there been longitudinal ABPM studies to describe the evolution of BP phenotype in girls with TS.

Objective: The primary objectives of this study are to provide an updated prevalence of sustained HTN, masked HTN, and nocturnal HTN in pediatric patients with TS using the 2022 ABPM guidelines in a large cohort of TS patients, compare patterns on first ABPM between patients with TS and age- and sex-matched controls, and describe the evolution of BP phenotype in patients with TS and multiple ABPM studies. Secondary objectives will include examining the association of ABPM findings with structural renal anomalies, left ventricular hypertrophy, and ambulatory arterial stiffness index among girls with TS.

Design/Methods: This is a single-center, retrospective study where screening ABPM is performed in all patients with TS from 2007-2024. Age-and sex-matched patients who have undergone ABPM for elevated BP will serve as controls. All ABPM studies will be interpreted using the 2022 AHA ABPM guidelines. Institutional review board approval has been obtained through Seattle Children’s Hospital and completion of data collection is expected by January 2025. Data analysis will include descriptive statistics on the prevalence of ABPM phenotypes as well as evolution of ABPM findings over time. Comparative analysis of patients with TS and controls will also be performed. Data analysis is expected to be complete by March 2025.