WIP 77 - Frequency of CMV infection and other abnormal diagnostic findings in Small for Gestational Age Neonates in South Bronx

Publication Number: WIP 77.7437

Sevara Sultanova, Bronxcare Health System - - Bronx, NY, Bronx, NY, United States; Olaseni P. Prince, Bronxcare Health System, Bronx, NY, United States; James Okereke, BronxCare Health System, Bronx, NY, United States; Adekunle Oke, Bronxcare Health System, Bronx, NY, United States; Pratika Mikkilineni, Bronxcare Health System, New York, NY, United States; Pratibha Ankola, Icahn School of Medicine at Mount Sinai, Bronx, NY, United States

Background: Small for gestational age (SGA) infants are defined as a newborns under the 10th percentile for their respective gestational age, gender and population. Neonates born SGA are categorized into 2 groups: asymmetric SGA neonates - neonates with a head circumference within the reference range of appropriate and symmetric SGA neonates - neonates with a head circumference and weight below the reference range of appropriate. There are various associations between size according to gestational age and both long and short term metabolic, developmental, neurological morbidities and in some cases, increased mortality. SGA is a multifactorial consequence from both maternal and placental factors. The most significant and common risk factor is cytomegalovirus infection (CMV). Because of the devastating consequence of sensorineural hearing loss and other associated morbidities clinicians should have a low threshold to test the SGA neonates for congenital CMV infection.

Objective: To evaluate the frequency of CMV infection and other abnormal diagnostic findings in Small for Gestational Age Neonates in South Bronx population

Design/Methods: Our study is a descriptive retrospective cohort study, looking particularly at neonates Small for Gestation Age (SGA) born in and admitted to the NICU/Nursery of BronxCare Hospital between the years 2018-2023. We received IRB approval on November 9,2023. Our sample included neonates, born SGA determined by International Classification of Diseases (ICD) codes. Our sample was further divided into 2 groups: symmetric SGA and asymmetric SGA. We measured the incidence of CMV infection in symmetric SGA neonates. Additionally, we reviewed other associated abnormal findings on either examination ie, failed newborn hearing screen, eye examination or radiologic findings: ie, cranial ultrasound and other neuroimaging modalities. Our exclusion criteria were neonates with congenital conditions affecting growth, Large for gestational age (LGA) and Appropriate for Gestational Age (AGA).