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Evaluation ViewAttendees 18

Academic and Research Skills

Asthma

Basic Science

Developmental Biology

Pulmonology

Trainee
Session Type: Hot Topic Symposia

Application of Human Lung Organoids in Disease Modeling

Sunday, April 27, 2025
2:00pm – 3:30pm HST
Location: Convention Center: 313 B
CE: 1.5

Selected By: PAS Program Committee Leadership Team
Disclosure(s):
Sandra L. Leibel, MD MS: I do not have any relevant financial / non-financial relationships with any proprietary interests.

In recent years, human lung organoids have emerged as a groundbreaking tool in disease modeling, offering unprecedented insights into lung biology and pathology. Although animal models have been important in uncovering mechanisms of lung development and disease, they fail to replicate the specificities of human cell responses. This session will explore the diverse applications of lung organoids in studying lung development, respiratory diseases, including interstitial pulmonary fibrosis, and viral infections.

Participants will learn about the latest advancements in organoid technology, including the development of patient-derived models that accurately replicate disease phenotypes. We will highlight how these organoids can be utilized to dissect disease mechanisms, assess drug responses, and evaluate therapeutic interventions in a controlled, in vitro environment.

Additionally, discussions will focus on the challenges and future directions of organoid research, including scalability, standardization, and the integration of organoids with other technologies like co-culturing with immune cells and gene editing.

Join us for an engaging session that promises to expand your understanding of lung organoids and their transformative potential in respiratory disease research and personalized medicine.

Learning Objectives:

  • Understand the advantages of using human lung organoids over traditional animal models in studying lung development and disease.
  • Explore applications in disease modeling including patient specific lung diseases and acute viral infections.
  • Assess future directions in lung organoid research including advancements in personalized medicine and gene editing technologies

Presentations:

  • 2:00pm – 2:30pm HST
    Development of a Human Alveolar Organoid Model of Pulmonary Fibrosis to Understand Disease Mechanism and Screen Therapeutics

    Speaker: Chandani Sen, PhD (she/her/hers) – UCLA

  • 2:30pm – 3:00pm HST
    Synergistic Applications of Induced Pluripotent Stem Cells and Gene Editing for Innovative Lung Disease Modeling

    Speaker: Shimpei Gotoh, MD, PhD (he/him/his) – Center for iPS Cell Research and Application (CiRA), Kyoto University

  • 3:00pm – 3:30pm HST
    Revolutionizing Personalized Medicine: The Role of Lung Organoids in Tailoring Respiratory Disease Treatments

    Speaker: Sandra L. Leibel, MD MS (she/her/hers) – University of California, San Diego School of Medicine