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Evaluation ViewAttendees 57

Basic Science

Breastfeeding/Human Milk

Infectious Diseases

Neonatology

Pediatric Nutrition
Session Type: Club in Conv Center

Neonatal Sepsis Club: The microbiome as a protector and a perpetrator in neonatal sepsis: balancing clinical care for best outcomes

Sunday, April 27, 2025
12:25pm – 1:50pm HST
Location: Convention Center: 315
CE: 1.5

Disclosure(s):
Sagori Mukhopadhyay, MD, MMSc: I do not have any relevant financial / non-financial relationships with any proprietary interests.
David Kaufman, MD: I do not have any relevant financial / non-financial relationships with any proprietary interests.

The neonatal microbiome can be both a protector from and a source of pathogens resulting in sepsis. A better understanding of the neonatal microbiome can inform interventions to interrupt disease transmission, delineate risk for infection, and improve outcomes in infants with infection. Microbiome-based interventions to reduce sepsis seek to either strengthen its protective role by supporting a diverse ecosystem or reduce its potential as a reservoir for opportunistic pathogens. However, these strategies can counteract each other unless carefully tailored to the context. Currently, the risk-benefit of interventions modifying the microbiome to improve infection risk remains an area of active research. In this session we discuss the evolving understanding of the role of the microbiome that can inform clinical choices and identify direction for future research.

Learning Objectives:

  • Identify microbial and host signatures that are linked with a higher risk of infection
  • List clinical interventions that aim to modulate the microbiome for clinical benefit
  • Discuss the potential risk and benefits of microbiome modulation

Presentations:

  • 12:25pm – 12:30pm HST
    Introduction: The Microbiome as a Protector and a Perpetrator in Neonatal Sepsis: Balancing Clinical Care for Best Outcomes

    Speaker: Carolyn M. McGann, MD (she/her/hers) – Childrens Hospital of Philadelphia

  • 12:30pm – 1:00pm HST
    Unravelling the Role of the Microbiome in Neonatal Sepsis

    Speaker: Drew Joel Schwartz, MD, PhD (he/him/his) – Washington University School of Medicine

  • 1:00pm – 1:30pm HST
    Translating Insights from Microbiome Research into Improved Clinical Practices for Neonates

    Speaker: Barbara Warner, MD, MSci (she/her/hers) – Washington University in St. Louis School of Medicine

  • 1:30pm – 1:40pm HST
    Update on the NANO trial

    Speaker: Richard A. Polin, MD – Columbia University Vagelos College of Physicians and Surgeons

  • 1:40pm – 1:50pm HST
    Panel Discussion

    Speaker: David Kaufman, MD – University of Virginia