Advancing Precision Medicine by Measuring ACEs, Toxic Stress, and Intervention Efficacy with Policy Implications

Chair(s)

• 

  David Reiner, PhD (he/him/his)

  Chief Science Officer
  California Health and Human Services
  Sacramento, California, United States

This session will feature a state research program that addresses the health impacts of adverse childhood experiences (ACEs) with a precision medicine framework. Speakers will present data at the intersection of ACEs, toxic stress, biomarkers, and implementation science and describe policy implications. Dr. Reiner will describe a state-based model for research funding to advance precision medicine and applications to understanding the health impacts of ACEs. Dr. Glynn will share findings from 33,000 children screened for both ACES and an understudied aspect of ACEs, unpredictability in the household and family environment, which suggests screening for unpredictability will augment outcome prediction beyond existing recommendations in pediatric primary care. Dr. Levitt will describe two highly scalable biological measures of ACEs to improve early detection of toxic stress and resilience: mitochondria DNA and RNA and child novelty-induced heart rate variability. Dr. Marie-Mitchell will describe a pediatric intervention designed to address and reduce stress for children impacted by ACEs and share preliminary data on biomarkers associated with Child-ACEs. Drs. Sinder and Gilgoff will describe a systems-based approach for biomarkers on stress and trauma in adults impacted by ACEs and share how this approach can advance the development of comprehensive assessment tools and individualized interventions for Social Drivers of Health and toxic stress. Dr. Slavich will present data on the efficacy of a precision intervention for stress and resilience to reduce toxic stress in adults with elevated perceived stress levels impacted by ACEs, as well as how ACEs influence multisystem biological functioning.

Presentations:

• 7:00am – 7:05am HST

  Introduction
  

  Speaker: David Reiner, PhD (he/him/his) – California Health and Human Services
• 7:05am – 7:10am HST

  A state-based precision medicine research approach to address the health impacts of ACEs
  

  Speaker: David Reiner, PhD (he/him/his) – California Health and Human Services
• 7:10am – 7:25am HST

  Unpredictability: A Novel Adverse Childhood Experience
  

  Speaker: Laura M. Glynn, PhD (she/her/hers) – Chapman University
• 7:25am – 7:40am HST

  Family First Study: Scalable Measures of Toxic Stress for Clinical Deployment
  

  Speaker: Pat Levitt, PhD – Children\'s Hospital Los Angeles and University of Southern California
• 7:40am – 7:55am HST

  Building Resilient Families Through Pediatric Practice
  

  Speaker: Ariane Marie-Mitchell, MD, PhD, MPH (she/her/hers) – Loma Linda University Children's Hospital
• 7:55am – 8:02am HST

  A Multidisciplinary Systems Approach to Biomarkers and Precision Medicine: Study Methodology and Preliminary Results
  

  Speaker: Sayantani B. Sindher, MD (she/her/hers) – Stanford University School of Medicine
• 8:02am – 8:10am HST

  A Multidisciplinary Systems Approach to Biomarkers and Precision Medicine: Stress Biology & Precision Medicine
  

  Speaker: Rachel Gilgoff, MD, FAAP (she/her/hers) – Rachel Gilgoff
• 8:10am – 8:25am HST

  A Precision Intervention for Reducing Stress and Enhancing Resilience
  

  Speaker: George M. Slavich, Ph.D. (he/him/his) – UCLA
• 8:25am – 8:30am HST

  Closing Discussion
  

  Speaker: David Reiner, PhD (he/him/his) – California Health and Human Services

  Speaker: Laura M. Glynn, PhD (she/her/hers) – Chapman University

  Speaker: Pat Levitt, PhD – Children\'s Hospital Los Angeles and University of Southern California

  Speaker: Ariane Marie-Mitchell, MD, PhD, MPH (she/her/hers) – Loma Linda University Children's Hospital

  Speaker: Sayantani B. Sindher, MD (she/her/hers) – Stanford University School of Medicine

  Speaker: Rachel Gilgoff, MD, FAAP (she/her/hers) – Rachel Gilgoff

  Speaker: George M. Slavich, Ph.D. (he/him/his) – UCLA