SPR Basic/translational Research Assembly

Friday, April 25, 2025

4:00pm – 5:30pm HST

Location: Convention Center: 327

CE: 1.5

Selected By: SPR
Co-sponsored By: CHTRC

Chair(s)

CA

Cristina Alvira, MD (she/her/hers)

Professor of Pediatrics
UCSF Benioff Children's Hospital
San Francisco, California, United States

Disclosure(s):

Cristina M. Alvira, MD: I do not have any relevant financial / non-financial relationships with any proprietary interests.

The SPR Research Assemblies are designed to present innovating, state of the art research that is cross-disciplinary and not focused on a single clinical specialty. The session will bring together four featured platform speakers (selected from high-scoring abstracts submitted to PAS 2025, and prioritizing early career investigators) with one invited speaker, who will be an established investigator. This session will have two major goals. First, to facilitate connections between researchers untied by a thematic research focus, who would normally be delegated to different PAS sessions. Second, to feature high impact/cutting research projects that complement an invited speaker presentation.

Learning Objectives:

1. Identify new methodologies allowing the identification of cellular and molecular- mechanisms underlying pediatric diseases.
2. Understand how collaboration and information exchange across specialties can enhance the impact of research and result in larger discoveries.
3. Describe how a deep understanding of cellular mechanisms can be leveraged into novel therapies to diagnose or treat pediatric illness.

Presentations:

4:00pm – 4:05pm HST

Introduction
Speaker: Cristina M. Alvira, MD (she/her/hers) – UCSF Benioff Children's Hospital
4:05pm – 4:20pm HST

Using Genetics, Genomics, and Transcriptomics to Identify New Therapeutic Targets in Juvenile Idiopathic Arthritis
Presenting Author: Jim Jarvis, MD (he/him/his) – University of Washington School of Medicine
4:20pm – 4:35pm HST

Identifying Distinct and Overlapping Cell States Induced by Common Respiratory Viruses in the Pediatric Nasal Mucosa
Presenting Author: Lillian Juttukonda, MD, PhD – Boston Children's Hospital
4:35pm – 4:55pm HST

Deciphering Pediatric RSV Pathobiology: Innate Immune Dysfunction in Critical Illness
Speaker: Melody G. Duvall, MD, PhD – Harvard Medical School
4:55pm – 5:10pm HST

Development of the Preterm Infant Immune System is Shaped by Clinical Events
Presenting Author: Benjamin Fensterheim, MD, PhD (he/him/his) – Childrens Hospital of Philadelphia
5:10pm – 5:25pm HST

Effect of Myeloid-Derived Suppressor Cells (MDSC) on T-cell Function in Children with Staphylococcus aureus (SA) Bacteremia
Presenting Author: Jordan Brauner, MD (she/her/hers) – Nationwide Children's Hospital
5:25pm – 5:30pm HST

Closing
Speaker: Cristina M. Alvira, MD (she/her/hers) – UCSF Benioff Children's Hospital