523 - Neurodevelopmental outcomes at 24 months after the Stockholm Preterm Interaction-Based Intervention

Publication Number: 523.5856

Anna Hallin Provenzano, Karolinska Institutet, Stockholm, Stockholms Lan, Sweden; Noni Wadström, Karolinska University Hospital, Danderyd, Stockholms Lan, Sweden; Kristina Löwing, Karolinska Institutet, Stockholm, Stockholms Lan, Sweden; Erika Baraldi, Department of Special Education, Stockholm, Stockholms Lan, Sweden; Mara Westling Allodi, Stockholm University, Stockholm, Stockholms Lan, Sweden; Ann-Charlotte Smedler, Stockholm university, SE-106 91 Stockholm, Stockholms Lan, Sweden; Maria Örtqvist, Karolinska Insitutet, Stockholm, Stockholms Lan, Sweden; ulrika Åden, Karolinska and Linköping, Stockholm, Stockholms Lan, Sweden

Background: Extremely preterm birth (EPT, < 28 weeks gestational age) presents a significant threat to an infant’s survival, health and development. There is increasing evidence that early interventions may have an effect on children born preterm. There are no previous studies on early post discharged interventions in the Swedish context and in children born EPT. The Stockholm Preterm Interaction-based intervention, (SPIBI) was developed and the primary outcome showed no general effect on parent-child interaction at four months, but improved child interaction in a subgroup of children (Baraldi et al 2024). Secondary outcomes were to evaluate the effect of the intervention regarding neurodevelopmental outcomes at 24 months, corrected age (CA).

Objective: The objective was to evaluate the effect of SPIBI on cognitive, language and motor outcomes at 24 months CA.

Design/Methods: The study is an RCT including 130 families (69 boys, GA median 26w (22-27)) with infants born EPT in Stockholm county recruited between 2018-2021. The intervention group (n=66) received a strength-based intervention supporting parent-child interaction (SPIBI) during their first year and the control group (n=64) received standard follow-up. At 24 months CA the Bayley Scales of Infant and Toddler Development – 3rd ed (BSID-III) was used to evaluate cognition, language and motor outcome.

Results: In total 97 infants (56 boys, GA median 26w (22-27w), BW median 798g (448-1326g)) were assessed with the BSID-III (gross motor n=97, fine motor n=96, cognition n=92, language n=90) at 24 months CA. No significant differences in cognition, language or motor scores were found between the intervention and control group (p>0.05) (Table I).

Conclusion(s): No significant effect of the SPIBI was seen on cognition, language or motor outcomes in the intervention group compared to the control group. Overall, 26% of all the children had a mild to severe motor delay (index score < 85). Regarding language and cognition, 70% and 85% respectively had a mild to severe delay (index score < 85) at 24 months CA.

Table I.